Neck Rejuvenation Treatments Using Biostimulators. The skin of the neck is one of the most delicate areas, where signs of aging appear particularly early. Reduced density, loss of tone, and the appearance of fine lines require not merely concealment, but a deep restoration of tissue quality. Advanced biostimulators—such as Sculptra, Esthefill, Profhilo, and PDRN—allow for treatment at the skin's structural level, gradually restoring density, elasticity, and natural support. While each substance has a different mechanism of action, they all share a common goal: not to create artificial volume, but to activate the skin's natural regeneration processes. • Sculptra / Esthefill stimulate collagen production and strengthen the skin's structural framework.